CBX - China Biotech XYZ

BeBetter Med has submitted the IND application for BEBT-507, a siRNA that targets TMPRSS6, in patients with iron metabolism disorders ( Polycythemia Vera, Disease of Iron Overload, etc.) . This marks BeBetter's first potential RNAi therapy to reach the clinical stage. The second siRNA therapy targets  NAFLD/MAFLD. BEBT-507 TMPRSS6 is a serine protease expressed in the liver that negatively regulates the iron-regulatory hormone hepcidin. Using siRNA to silence TMPRSS6 can increase hepcidin levels, offering a therapeutic approach for iron overload and related conditions. TMPRSS6 BEBT-507 is a GalNac-conjugated siRNA targeting TMPRSS6 as a treatment for patients with  Polycythemia Vera and  β-thalassemia. The patent (WO2024109722 ) filed by BeBetter in 2022 showed the in vivo efficacy of several examples such as BBD-2051.210-GalNac in comparison with  Divesiran  . Patent TMPRSS6 Therapies in the Clinical Stage Different technology modalities, such as ASO, siRNA, and antibody, are bein