CBX - China Biotech XYZ

 On December 26, 2023, Leado Pharmatech filed an IND application for LD09163 a TRPA1 inhibitor, in China.  According to their pipeline information on the website, LD09163 is specifically designed for patients with ulcerative colitis and Crohn's disease. Companies such as Lilly have explored the use of their TRPA1 inhibitor for pain relief before. As reported by Yiding Chen , " In animal studies, mice with experimental colitis exhibited an increased TRPA1-mediated colonic neuropeptide release, while the experimental colitis appeared to be less severe after the inhibition of TRPA1 by the antagonist or genetic depletion." https://doi.org/10.3389/fimmu.2020.00180 LD09163 is a novel ion channel drug developed by Leado Pharmatech for the treatment of Inflammatory Bowel Disease (IBD). After oral administration, it can selectively accumulate in the gastrointestinal tract, increasing drug concentration in target tissues and reducing systemic toxicity. Its performance in various ef