CBX - China Biotech XYZ

 Sintanovo, a company of Sun-Novo,  has submitted the IND application for the  peptide  GHSR-1a agonist  STC008. This is the second Class 1 new drug candidate , following the first clinical-stage STC007, a peptide KOR agonist for postoperative pain relief . STC008 Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, a class A G protein-coupled receptor (GPCR), plays a diverse role in physiological functions, such as regulating appetite, alcohol intake, adipocyte metabolism, and maintaining glucose balance. GHSR1a, by binding with ghrelin, plays a significant role in stimulating appetite and increasing food intake. The role of GHS-R is thought to be in regulating energy homeostasis and body weight In 2020, anamorelin, a ghrelin receptor agonist, was approved as the world's first drug for the treatment of cancer cachexia in malignant tumors of non-small cell lung cancer, gastric cancer, pancreatic cancer, or colorectal cancer in Japan.  Unlike megestrol or cor